Now since they are specifically designed for PCs, can’t get run on macOS. exe extensions are actually executable files… compiled for Windows. The simple answer to this question is ‘ NO’… So, is this actually true…? Quickly have a look at the answer to this question… exe files on macOS… there is a rumor about these files that they can get open on Mac. So, these are the effective ways which you can go for when it’s about How to open EXE files on Mac Catalina or any other version…īefore coming on ways on how to open. One another and very popular way to run exe files on macOS is to install Windows 10 on your Mac, via using Boot Camp partition… Or, you can go for a Virtual Machine, which allows you to run Windows 10 on your macOS Big Sur or earlier. It usually gets tedious to run Windows software on a Mac system… due to compatibility issue… However, this can get done with the means of a specialized tool that lets you open. 4.1 Packed with several powerful algorithmic skills, the software does include the potential of:.